Whole-Brain Circuit Reconstruction
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Mammalian whole-brain neural circuit reconstruction is fast approaching reality, with the mouse brain being the first target. These types of maps will provide complete wiring diagrams at the synaptic-level for the whole brain, allowing for the first time an understanding of how the most complicated thing in the known universe is put together.
Rapid progress is being made. Stay tuned.  |
"Progress Towards Mammalian Whole-Brain Cellular Connectomics" is now online
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Join Us at Janelia Farm's Neural Circuit Reconstruction Conference in Ashburn, VA, and FENS 2016 in Copenhagen
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At Janelia Farm, we will talk over "Mammalian whole-brain preparation for neural circuit reconstruction", and at FENS, we will talk over "Whole-Brain Electron Microscopic Circuit Reconstruction" at the FENS symposium, "From structure to function: multiscale approaches to mouse brain connectivity mapping". |
Our whole-brain staining for circuit reconstruction paper on the cover of Nature Methods
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Join Us at SFN 2015 in Chicago
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Advances in high-resolution, high-throughput whole mouse brain volume electron microscopy. Tuesday Oct 20, 2014 1:00 PM - 5:00 PM Number: DD47  |
The BROPA Brain has arrived!
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A milestone towards whole mouse brain neural circuit reconstruction has been reached. See our new publication over Whole-Brain Staining for Neural Circuit Reconstruction at the Publications page or read the official press release.
Flying through the striatum of a BROPA mouse brain. You can access this data now by following these instructions. |
Multibeam Electron Microscopy for High-Throughput Imaging
| There is a new publication over multibeam electron microscopy. Fig. 2 is from our whole mouse brain sample. Special thanks to Zeiss. See the Publications page for more. |
Join Us at SFN 2014 in D.C.
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Towards whole-mouse-brain serial block-face electron microscopy. -- S Mikula & W Denk Saturday Nov 15, 2014 1:00 PM - 5:00 PM Number: TT73  |
Whole-Brain Circuit Mapping Featured in Nature
Combining enhanced whole-brain staining with high-throughput electron microscopy will lead to circuit reconstruction of the whole mouse brain
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Join Us at SFN 2013
Tue, Nov 12, 1:00 - 5:00 PM, 677.12/LLL55 - Enhanced staining for whole mouse brain circuit reconstruction
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The Road to the Whole Brain
The path to mapping the complete circuit of the whole mouse brain is shown below. 
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Staining the Whole Mouse Brain for Electron Microscopy
Our new article has appeared in Nature Methods over staining the whole mouse brain and evaluating axon traceability. Read more about it at the Nature website and in the Max Planck Institute press release .
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Whole-Brain Ultrastructural Mapping in the Mouse
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Brain Preservation Contest
We have entered the Brain Preservation Contest, whose first goal is optimal whole-brain ultrastructural preservation in the mouse.
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Join Us at SFN 2011
Sun, Nov 13, 2:00 - 3:00 PM, 304.14/XX66 - Whole-brain ultrastructural staining in the mouse
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